Members of the crowd reportedly started throwing their plastic cups at Culkin and his band as they performed at a Manchester venue on Friday.
The 33-year-old actor was interrupted during his kazoo solo by a gig-goer, according to latest reports.

The actor is on his first UK tour with his band (Splash News)
It is understood that Culkin returned to the stage but the show ended immediately after fans tried to invade the stage.
According to the Mirror, one witness said: "It was the weirdest thing I've ever watched. It was just bizarre."
Meanwhile, last night the band were also forced to cut short their set at the Dot to Dot festival in Nottingham after being booed.
"Why are you throwing those? I'd rather drink them," Culkin asked the audience, reports the Nottingham Post.
The gigs have been part of The Pizza Underground's first UK tour.
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